The Pima County Attorney's Homicide Unit prosecutes the majority of the murder cases that occur in Pima County. High profile and more complicated homicides are assigned to senior attorneys who have from 15 to 30 years of prosecution experience. These attorneys work with the newer prosecutors to help them gain experience in homicide prosecution. The attorney is involved throughout the case from the beginning, when called out to the scene, to the end through to sentencing.

The unit works with all local, state and federal law enforcement agencies in Pima County. A panel of senior prosecutors has a monthly review of active homicide cases. This review includes such things as whether the State should seek the death penalty to whether a plea offer should be offered/accepted on any case.